KMCT Medical College was established in the year 2008 with an intake of 100 MBBS seats approved by the Medical Council of India. The College is affiliated with Kerala University of Health Sciences. The Central Government had accorded recognition for the MBBS course in the year 2013. Postgraduate courses were started in the academic year 2015-16 in Orthopaedics & Pharmacology and in the academic year 2020-21 postgraduate courses were started in other specialities (Microbiology, Community Medicine, General Medicine, General Surgery, Obstetrics & Gynaecology, Paediatrics, ENT, Ophthalmology, Dermatology, Anaesthesiology, Psychiatry, Radiology & Pulmonary Medicine). From the academic year 2024-25, the intake of students in MBBS course was increased from 150 to 250 by the approval of Central Government.

The Medical College is attached to KMCT Medical College Hospital, which is a tertiary level multispecialty hospital with more than 1200 beds. The hospital complex is well equipped & staffed with basic general units & supportive specialities. The hospital has well conducted Cardiology, Neurology & Nephrology departments. Our students have excelled in extracurricular activities and won trophies and medals in arts & sports conducted by Kerala University of Health Sciences, Thrissur. They have also won top positions in quiz competitions conducted in various disciplines of medical science at intercollegiate levels. The college has an Alumni Association which meets every year, and also provide valuable suggestions for the improvement of the Institution.

The pass percentage of the students, who were admitted in the 2008 batch and have completed the course in 2013 is 100 which is the highest in Kerala. Thereafter, two other batches have completed the course with a pass percentage of 96.2 and 86.88, which is again the highest percentage of pass both under the Calicut University as well as under the 3rd respondent University. Students of this college have secured high positions in the All India Post Graduate Medical Entrance Examination with Rank No.10 as well as in the Kerala Post Graduate Medical Entrance Examination with Rank no.10 and 15. There are candidates who have secured Rank No.50, 91, 130 and so on in the postgraduate entrance examinations. Many of the students of this college are pursuing their higher studies in institutions with national importance. One of our students of 2009 batch was the second rank holder in the 1st MBBS University Examination under University of Calicut. In 2010 batch another student got the Gold medal for securing the top position in Anatomy of the Ist MBBS Examinations under KUHS. In 2013 batch one student got the 15th rank in the first MBBS Examination.